I don't quite follow what you're asking for.

For what it may be worth, the use of a settings.py file as in Django is something that I've adopted for other non-Django projects. It makes my life easier, in that it is a slightly formalized, conventionalized way of adding a method of configuration to a specific project.

Because C programmers have to compile for their code to run, and Python programmers don't. So having another file is "excise" - i.e., work that doesn't assist the developer in reaching their own goals.